Semaglutide 15mg

Semaglutide is a selective agonist at the GLP-1 receptor, a class B G-protein coupled receptor. Receptor engagement activates Gas, elevates intracellular cAMP, and recruits beta-arrestin-1 with kinetics modified by the fatty acid modification. In pancreatic beta cells, this signaling potentiates glucose-stimulated insulin secretion, a glucose-dependent action that limits the risk of hypoglycemia in research models.

Within the hypothalamic arcuate nucleus, GLP-1 receptor activation depolarizes POMC neurons and inhibits AgRP neurons, an effect demonstrated by electrophysiological recordings in murine slice preparations. Engagement of receptors in the area postrema and nucleus tractus solitarius contributes to observed reductions in food intake and delayed gastric emptying. In rodent reward circuits, semaglutide has been shown to modulate dopamine release in the nucleus accumbens, providing a mechanistic basis for ongoing research into addictive behaviors.