Melanotan II 10mg· 10mg

Melanotan II engages all five melanocortin receptor subtypes (MC1R through MC5R) as a non-selective agonist, with affinity for each receptor in the nanomolar to low-nanomolar range. All five receptors are class A G-protein coupled receptors coupled to Gas with downstream elevation of intracellular cAMP.

MC1R activation on melanocytes drives eumelanin synthesis through tyrosinase upregulation, producing the pigmentary effects characteristic of melanocortin signaling. MC4R activation in hypothalamic neurons engages central circuits regulating appetite, with effects observed on food intake in preclinical feeding studies. The same MC4R activation engages central sexual response circuits, producing the effects on sexual desire and erectile response that have been characterized in preclinical and early clinical research. MC3R and MC5R activations contribute additional effects on energy metabolism and on exocrine gland function, respectively. The cyclic lactam structure of the molecule confers conformational constraint that supports high-affinity binding at multiple receptor subtypes and provides resistance to proteolytic cleavage.