Ipamorelin 5mg· 5mg

Ipamorelin binds the growth hormone secretagogue receptor type 1a (GHSR-1a), a class A G-protein coupled receptor expressed on pituitary somatotrophs, hypothalamic arcuate nucleus neurons, and several peripheral tissues. Receptor activation couples primarily through Gq to phospholipase C-beta, generating inositol trisphosphate and mobilizing intracellular calcium. This calcium signal triggers exocytosis of stored growth hormone from somatotroph secretory granules.

The selective profile of ipamorelin compared with earlier GHRPs has been attributed to the specific conformational presentation of the pentapeptide at the GHSR-1a binding pocket, with reduced engagement of alternative signaling pathways or off-target receptors implicated in cortisol and prolactin release. When combined with GHRH receptor agonists such as sermorelin or modified GRF (1-29), ipamorelin produces synergistic growth hormone release, reflecting the complementary Gs and Gq signaling pathways activated by the two receptor systems in somatotrophs.