GHRP-2 10mg· 10mg

GHRP-2 binds the growth hormone secretagogue receptor type 1a (GHSR-1a) on pituitary somatotrophs, activating Gq-mediated phospholipase C signaling, elevating intracellular calcium, and triggering exocytosis of stored growth hormone. The hexapeptide also engages central nervous system GHSR-1a, contributing to the appetite-stimulating effects observed in preclinical models and to modest activation of the hypothalamic-pituitary-adrenal axis.

Mechanistic comparisons with ipamorelin have attributed the greater cortisol and prolactin response of GHRP-2 to broader engagement of central neuropeptide systems and possibly to activity at additional receptors beyond GHSR-1a. The downstream cortisol elevation appears to result from activation of corticotropin-releasing hormone neurons in the paraventricular nucleus rather than direct adrenocortical stimulation. Prolactin release likely reflects engagement of lactotrophs through indirect hypothalamic mechanisms.