Dihexa 20mg· 20mg

Dihexa has been characterized as a small-molecule facilitator of hepatocyte growth factor (HGF) binding to its receptor c-Met. The proposed mechanism involves the compound forming a complex with HGF that enhances its affinity for c-Met, effectively functioning as a positive allosteric modulator of HGF/c-Met interactions. Engagement of c-Met activates downstream tyrosine kinase signaling, including ERK and PI3K/Akt pathways implicated in neuronal survival and synaptic plasticity.

In hippocampal preparations, dihexa has been reported to increase dendritic spine density and to enhance synaptogenesis at concentrations in the picomolar to nanomolar range. These effects have been associated with improved synaptic transmission in electrophysiological recordings. Behavioral effects in aged rodents include preservation of spatial learning in Morris water maze paradigms, with mechanistic attribution to the synaptogenic effects in hippocampal circuits. The molecule retains aspects of Ang IV pharmacology, including binding to IRAP, though the relevance of IRAP engagement to the cognitive effects observed remains an area of continued investigation.