5-Amino-1MQ 150mg· 150mg

5-Amino-1MQ is a competitive, substrate-analog inhibitor of nicotinamide N-methyltransferase. The compound mimics the quinolinium structure of the enzyme's product 1-methylnicotinamide and binds in the active site, blocking the transfer of a methyl group from S-adenosylmethionine to nicotinamide. Inhibition is reversible and selective relative to other methyltransferases such as PRMTs and DNMTs in biochemical assays.

The downstream metabolic consequences of NNMT inhibition include preservation of cellular nicotinamide pools, which feed into the NAD+ salvage pathway via nicotinamide phosphoribosyltransferase. Researchers have observed elevations in adipocyte NAD+ following 5-Amino-1MQ treatment, with corresponding activation of sirtuin-dependent deacetylation events. Reduced consumption of S-adenosylmethionine spares this cofactor for histone and DNA methylation, potentially altering epigenetic gene regulation in adipose tissue. In murine models, these biochemical changes have been associated with increased lipolysis, reduced lipogenic gene expression, and decreased adipocyte size.